SULF1’s Role in Endothelial Senescence and Atherosclerosis: Insights from Single-Cell and Bulk Transcriptomics
Meng-Ting Jiang, Shi-Lei Wan, Xiang-Yu Shen, Zhong-Bai Zhang, Zhi-Qing He, Yang-Xi Hu, Chun Liang · 2025
Read SULF1’s Role in Endothelial Senescence and Atherosclerosis: Insights from Single-Cell and Bulk Transcriptomics by Meng-Ting Jiang, Shi-Lei Wan, Xiang-Yu Shen, Zhong-Bai Zhang, Zhi-Qing He, Yang-Xi Hu, Chun Liang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12717813.txt.
Description
Cells lining blood vessels age early inside artery plaques, and one enzyme's rise may mark that aging. Meng-Ting Jiang and co-authors tracked the enzyme, SULF1, in this 2025 study. Vessel-wall aging feeds plaque growth, the core of atherosclerosis. Data came from single-cell reads of plaque cores and nearby healthy tissue.
Bulk gene data from early and late plaques narrowed the suspect list. SULF1 stood out and was checked in mice prone to plaques and in human artery cells stressed with oxidized fat. Silencing the gene, protein blots, and aging stains all tested its role. A marker tied to vessel aging could guide drugs that keep arteries young. The multi-layer data design strengthens the claim.
Catalog record
| CREATOR | Meng-Ting Jiang, Shi-Lei Wan, Xiang-Yu Shen, Zhong-Bai Zhang, Zhi-Qing He, Yang-Xi Hu, Chun Liang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |