Association of iron metabolism with disease severity in acute Puumala hantavirus infection
Johanna Tietäväinen, Tuula Outinen, Ulla Nivukoski, Outi Laine, Satu Mäkelä, Heini Huhtala, Onni Niemelä, Ilkka Pörsti, Antti Vaheri, Jukka Mustonen · 2025
Read Association of iron metabolism with disease severity in acute Puumala hantavirus infection by Johanna Tietäväinen, Tuula Outinen, Ulla Nivukoski, Outi Laine, Satu Mäkelä, Heini Huhtala, Onni Niemelä, Ilkka Pörsti, Antti Vaheri, Jukka Mustonen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12717707.txt.
Description
Johanna Tietavainen and colleagues measured iron handling in Finnish patients during and after a hantavirus infection that attacks the kidneys. Ferritin, the iron storage protein, tracks severity in several bleeding fevers, and stray iron can injure kidney tissue. Writing in twenty twenty-five, the team analyzed blood from patients in the acute phase and again in recovery. Iron-related measures were compared with white cell counts, platelet counts, and kidney injury markers to see which aspect of illness they mirror.
In the acute phase, ferritin, the iron-regulating hormone hepcidin, and a kidney stress marker were all high, while circulating iron and its carrier protein were low. Ferritin and hepcidin tracked with high white cell counts and low platelet counts, signs of inflammation and bleeding risk. None of the iron measures tracked with kidney injury severity itself, a negative result the authors state plainly.
Catalog record
| CREATOR | Johanna Tietäväinen, Tuula Outinen, Ulla Nivukoski, Outi Laine, Satu Mäkelä, Heini Huhtala, Onni Niemelä, Ilkka Pörsti, Antti Vaheri, Jukka Mustonen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |