Radiation therapy causes a STING and MyD88-independent upregulation of CD80 and CD86 in macrophages and monocytes that limits tumor control
Aanchal Preet Kaur, Jason R. Baird, Alejandro F. Alice, Gwen Kramer, David Friedman, Eva Moran, Marka Crittenden, Michael J. Gough · 2025
Read Radiation therapy causes a STING and MyD88-independent upregulation of CD80 and CD86 in macrophages and monocytes that limits tumor control by Aanchal Preet Kaur, Jason R. Baird, Alejandro F. Alice, Gwen Kramer, David Friedman, Eva Moran, Marka Crittenden, Michael J. Gough (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12717329.txt.
Description
Aanchal Preet Kaur and colleagues published a tumor immunology study in 2025. They studied how radiation changes immune cells in tumors. Radiation plus T cells can control leftover cancer. Regulatory T cells expand after radiation and block control. The team used three-dimensional tumor models and live tracking. They watched macrophages and monocytes after radiation doses. Two surface molecules, CD80 and CD86, rose sharply. Common alarm pathways did not drive that rise. The finding was unexpected for immune activation markers.
Blocking those molecules improved tumor control after radiation. It also reduced regulatory T cell expansion greatly. Fewer helper T cells entered tumors under blockade. Inflamed myeloid cells seem to invite suppressive cells. Cutting that invitation freed killer T cell control. The work suggests a new combination treatment idea. Timing with radiation will need careful testing.
Catalog record
| CREATOR | Aanchal Preet Kaur, Jason R. Baird, Alejandro F. Alice, Gwen Kramer, David Friedman, Eva Moran, Marka Crittenden, Michael J. Gough |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |