Design, synthesis, and multi-target evaluation of 4-phenyl quinoline-8-sulfonate thiosemicarbazones as potential anti-Alzheimer agents
Rahma Saeed, Hafiza Zara Tariq, Aiysha Althobaiti, Nastaran Sadeghian, Parham Taslimi, Mariya Al-Rashida, Talha Islam, Hamdy Khamees Thabet, Hina Aftab, Halil Şenol, Mubashir Ameen, Jing Li, Zahid Shafiq · 2025
Read Design, synthesis, and multi-target evaluation of 4-phenyl quinoline-8-sulfonate thiosemicarbazones as potential anti-Alzheimer agents by Rahma Saeed, Hafiza Zara Tariq, Aiysha Althobaiti, Nastaran Sadeghian, Parham Taslimi, Mariya Al-Rashida, Talha Islam, Hamdy Khamees Thabet, Hina Aftab, Halil Şenol, Mubashir Ameen, Jing Li, Zahid Shafiq (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12717256.txt.
Description
Rahma Saeed and co-authors synthesize a family of compounds designed to strike Alzheimer's disease at several targets at once. Their 2025 paper builds eighteen variants on a quinoline sulfonate frame. One, bearing a fluorine-tagged ring, blocked three enzymes of brain signaling at once, and beat the reference drug clorgyline on one of them by a wide margin.
Single-target drugs have repeatedly disappointed in Alzheimer's, which is why the multi-target design is the point. The team characterized each variant spectroscopically and ranked their potencies. Several others in the series also inhibited significantly. The work is early chemistry, but it maps which decorations on the frame matter most.
Catalog record
| CREATOR | Rahma Saeed, Hafiza Zara Tariq, Aiysha Althobaiti, Nastaran Sadeghian, Parham Taslimi, Mariya Al-Rashida, Talha Islam, Hamdy Khamees Thabet, Hina Aftab, Halil Şenol, Mubashir Ameen, Jing Li, Zahid Shafiq |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |