Unveiling the cellular and molecular mechanisms of diabetic retinopathy with human retinal organoids
Lada Polešovská, Simona Trmačová, Canan Celiker, Eva Hrubá, Francisco Molina Gambin, Václav Chochola, Veronika Matušková, Eleni Beli, Tomáš Bárta · 2025
Read Unveiling the cellular and molecular mechanisms of diabetic retinopathy with human retinal organoids by Lada Polešovská, Simona Trmačová, Canan Celiker, Eva Hrubá, Francisco Molina Gambin, Václav Chochola, Veronika Matušková, Eleni Beli, Tomáš Bárta (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12717054.txt.
Description
Lada Polešovská and co-authors grow human retinas in a dish to study diabetic eye disease in this 2025 paper. Animal eyes often miss human retinal biology. Lab-grown retinal organoids, stressed with rising sugar, offer a closer model. Young organoids shrugged off the extra sugar with normal shape and gene activity.
Mature organoids fared worse. Light-sensing cells lost their key genes, shortened their outer segments, and died more often. Stress signals rose and support cells switched on. Comparing the data with human diabetic retina samples confirmed shared pathways. The authors offer the organoids as a human platform for the nerve damage behind diabetic vision loss.
Catalog record
| CREATOR | Lada Polešovská, Simona Trmačová, Canan Celiker, Eva Hrubá, Francisco Molina Gambin, Václav Chochola, Veronika Matušková, Eleni Beli, Tomáš Bárta |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |