Modelling co-development between the somites and neural tube in human trunk-like structures
Komal Makwana, Louise Tilley, Probir Chakravarty, Jamie Thompson, Peter Baillie-Benson, Ignacio Rodriguez-Polo, Naomi Moris · 2025
Read Modelling co-development between the somites and neural tube in human trunk-like structures by Komal Makwana, Louise Tilley, Probir Chakravarty, Jamie Thompson, Peter Baillie-Benson, Ignacio Rodriguez-Polo, Naomi Moris (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12717004.txt.
Description
Komal Makwana and co-authors grow human trunk-like structures in which backbone segments and the spinal cord form together, in this 2025 study. Stem cell embryo models let researchers watch early human development in a dish. These structures self-organized both tissues through their own signaling, with no notochord present.
Cell profiles matched human embryos at about four to five weeks of development. Lacking a notochord, the tissues took on back-side identities. Adding a key signal in rising doses flipped both tissues toward belly-side fates. Signals also ran the other way: cord cues switched on a gene in the segments, whose product then patterned the cord. The model exposes two-way talk in trunk building.
Catalog record
| CREATOR | Komal Makwana, Louise Tilley, Probir Chakravarty, Jamie Thompson, Peter Baillie-Benson, Ignacio Rodriguez-Polo, Naomi Moris |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 98 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |