In vitro and in vivo efficacy of the antimycobacterial molecule SQ109 against the human pathogenic fungus, Cryptococcus neoformans
Nour M. Alkashef, Ehab A. Salama, Ramu Anandakrishnan, Tony R. Hazbun, Micah V. Hoernig, Anne M. Brown, Christopher B. Lawrence, Mohamed N. Seleem · 2025
Read In vitro and in vivo efficacy of the antimycobacterial molecule SQ109 against the human pathogenic fungus, Cryptococcus neoformans by Nour M. Alkashef, Ehab A. Salama, Ramu Anandakrishnan, Tony R. Hazbun, Micah V. Hoernig, Anne M. Brown, Christopher B. Lawrence, Mohamed N. Seleem (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12716712.txt.
Description
Nour M Alkashef and co-authors test a drug made for one germ against a harmful fungus in a 2025 study. The fungus preys on people with weak defence, such as those with HIV, and good cures are few and harsh. The team screened thousands of known drugs and clinic compounds for hits.
The chosen drug killed the fungus in dishes and kept killing as dose rose. The fungus showed little drift toward defiance under stress, unlike two standard drugs. In mice, half the treated group lived through the course, and the drug also boosted a standard cure when paired.
Catalog record
| CREATOR | Nour M. Alkashef, Ehab A. Salama, Ramu Anandakrishnan, Tony R. Hazbun, Micah V. Hoernig, Anne M. Brown, Christopher B. Lawrence, Mohamed N. Seleem |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |