Safety and potential efficacy of DM199, a tissue kallikrein-1 analogue, for treating pre-eclampsia and fetal growth restriction: study protocol for a South African, hospital-based phase I/II open-label trial
Catherine Anne Cluver, Jacquline Thake, Tasleem Hassim, Anriette van Greunen, Samantha Budhram, Karusha Knipe, Eric Decloedt, Lucy Brink, Eduard Langenegger, Lina Bergman, Henrik Imberg, Adrie Bekker, Susan P Walker, Stephen Tong · 2025
Read Safety and potential efficacy of DM199, a tissue kallikrein-1 analogue, for treating pre-eclampsia and fetal growth restriction: study protocol for a South African, hospital-based phase I/II open-label trial by Catherine Anne Cluver, Jacquline Thake, Tasleem Hassim, Anriette van Greunen, Samantha Budhram, Karusha Knipe, Eric Decloedt, Lucy Brink, Eduard Langenegger, Lina Bergman, Henrik Imberg, Adrie Bekker, Susan P Walker, Stephen Tong (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12716557.txt.
Description
Catherine Cluver and a large team set out a trial protocol for DM199, a lab-made copy of the enzyme tissue kallikrein-1, against pre-eclampsia and poor fetal growth. Both conditions lack drug treatments, and this enzyme frees bradykinin, which widens blood vessels and may raise flow to the placenta. The early-phase trial runs at Tygerberg Hospital in South Africa.
The first part climbs doses in women with severe disease near planned birth, hunting a dose that safely lowers blood pressure. The second part tests safety in three groups of thirty women, including very early disease. Cord blood levels, side effects and drug handling are the main reads.
Catalog record
| CREATOR | Catherine Anne Cluver, Jacquline Thake, Tasleem Hassim, Anriette van Greunen, Samantha Budhram, Karusha Knipe, Eric Decloedt, Lucy Brink, Eduard Langenegger, Lina Bergman, Henrik Imberg, Adrie Bekker, Susan P Walker, Stephen Tong |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |