Induction of antigen-specific regulatory T cells by engineered extracellular vesicles
Shota Imai, Kanto Nagamori, Uryo Onishi, Xiabing Lyu, Iriya Fujitsuka, Makie Ueda, Tomoyoshi Yamano, Rikinari Hanayama · 2025
Read Induction of antigen-specific regulatory T cells by engineered extracellular vesicles by Shota Imai, Kanto Nagamori, Uryo Onishi, Xiabing Lyu, Iriya Fujitsuka, Makie Ueda, Tomoyoshi Yamano, Rikinari Hanayama (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12716476.txt.
Description
Shota Imai and seven co-authors engineered tiny cell-made parcels that teach the immune system to stand down against one chosen target, in this 2025 study. Lasting tolerance would help autoimmune and allergy patients, but blunt drugs suppress everything. Their parcels display three signals on the surface: the target antigen on its presenting molecule, plus two calming messengers.
In dishes, the parcels turned naive immune cells into antigen-specific regulatory T cells carrying the classic calming markers. In mice, pairing the parcels with a low dose of rapamycin boosted those cells further. The induced cells actively suppressed other immune responses in tests. The authors present the design as a modular, cell-free route to precise tolerance.
Catalog record
| CREATOR | Shota Imai, Kanto Nagamori, Uryo Onishi, Xiabing Lyu, Iriya Fujitsuka, Makie Ueda, Tomoyoshi Yamano, Rikinari Hanayama |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |