Mapping drug distribution using CT imaging following direct tissue injection in ex vivo liver: informing clinical implementation
Robert Morhard, Michal Mauda-Havakuk, Jose F Delgado, Michael T Kassin, Azam Ghafoor, Ira Pastan, Raffit Hassan, John W Karanian, William F Pritchard, Bradford J Wood, Andrew S Mikhail · 2025
Read Mapping drug distribution using CT imaging following direct tissue injection in ex vivo liver: informing clinical implementation by Robert Morhard, Michal Mauda-Havakuk, Jose F Delgado, Michael T Kassin, Azam Ghafoor, Ira Pastan, Raffit Hassan, John W Karanian, William F Pritchard, Bradford J Wood, Andrew S Mikhail (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12716157.txt.
Description
Robert Morhard and co-authors test whether a CT contrast agent can map where a drug spreads after direct injection into liver tissue. Their 2025 study addresses a delivery route that lowers total dose and side effects versus whole-body dosing. Leakage at the injection site can make spread uneven and harm nearby tissue.
They injected a fluorescent stand-in drug together with an iodine contrast agent into cow liver outside the body. The iodine spread over a far larger volume than the stand-in, though the two volumes tracked each other. The agents differ in size and charge, which explains the gap. Scans at several injected volumes let the team model the relation. The work informs how image-guided injection trials can estimate real drug reach from a scan.
Catalog record
| CREATOR | Robert Morhard, Michal Mauda-Havakuk, Jose F Delgado, Michael T Kassin, Azam Ghafoor, Ira Pastan, Raffit Hassan, John W Karanian, William F Pritchard, Bradford J Wood, Andrew S Mikhail |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |