Challenges in laboratory diagnosis and antibiotic treatment options for a newly described Pseudomonas aeruginosa class A beta-lactamase type GES-62 strain
Thanh Tuyen Pham, Nils Mungard, Niels Pfennigwerth, Jessica Eisfeld, Sören Gaterman, Sandra Ehrhardt, Milica Lazarevic, Ines Weber, Sylke Lenz-Vogt, Nadine Martzsch, Sebastian Groß, Daniel Ebert, Marta Banach-Schmelzer, Stephan Krieger, Desislava Pantke-Zidarova, Matthias Beese, Askar Yerken, David · 2025
Read Challenges in laboratory diagnosis and antibiotic treatment options for a newly described Pseudomonas aeruginosa class A beta-lactamase type GES-62 strain by Thanh Tuyen Pham, Nils Mungard, Niels Pfennigwerth, Jessica Eisfeld, Sören Gaterman, Sandra Ehrhardt, Milica Lazarevic, Ines Weber, Sylke Lenz-Vogt, Nadine Martzsch, Sebastian Groß, Daniel Ebert, Marta Banach-Schmelzer, Stephan Krieger, Desislava Pantke-Zidarova, Matthias Beese, Askar Yerken, David (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12715562.txt.
Description
Thanh Tuyen Pham and colleagues report a new drug resistance enzyme in a Pseudomonas aeruginosa strain, and the lab trouble it caused. Carbapenem resistance in this bacterium is a growing world threat. Gene sequencing of the whole genome showed a variant of the GES beta-lactamase family that no one had seen before, named GES-62. The strain fought off many drugs. It came from the lungs of a sixty-one-year-old man with pneumonia, whose lungs were failing. He died when no treatment options remained.
Standard lab tests can miss or misread such enzymes, delaying therapy that works and infection control. The team details the detection challenges this variant posed. They also review which antibiotics, if any, still act against it. The 2025 report argues for fast carbapenemase tests in routine labs, before the next variant surprises another hospital.
Catalog record
| CREATOR | Thanh Tuyen Pham, Nils Mungard, Niels Pfennigwerth, Jessica Eisfeld, Sören Gaterman, Sandra Ehrhardt, Milica Lazarevic, Ines Weber, Sylke Lenz-Vogt, Nadine Martzsch, Sebastian Groß, Daniel Ebert, Marta Banach-Schmelzer, Stephan Krieger, Desislava Pantke-Zidarova, Matthias Beese, Askar Yerken, David |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 7 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |