Oxidative stress, mitochondrial dysfunction, and ferroptosis in the placenta of gestational diabetes mellitus
Xuan Zhou, Huiting Zhang, Lijie Wei, Zizhuo Wang, Shenglan Zhu, Jun Yu, Shaoshuai Wang, Wencheng Ding, Ling Feng, Jianli Wu · 2025
Read Oxidative stress, mitochondrial dysfunction, and ferroptosis in the placenta of gestational diabetes mellitus by Xuan Zhou, Huiting Zhang, Lijie Wei, Zizhuo Wang, Shenglan Zhu, Jun Yu, Shaoshuai Wang, Wencheng Ding, Ling Feng, Jianli Wu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12714824.txt.
Description
Xuan Zhou and co-authors review how damage inside the placenta may drive diabetes in pregnancy in a 2025 paper. Gestational diabetes is rising, and its inner causes remain partly hidden. The placenta sits between mother and fetus, burns large amounts of energy, and leaks hormones that blunt insulin. Flooding that organ with sugar sparks oxidative stress, the chemical wear caused by reactive oxygen.
Stressed power plants inside cells then fail, and an iron-driven form of cell death called ferroptosis follows as fats oxidize. The review gathers five years of work tying these three steps into one chain. Seeing the chain whole points to where a drug or diet change might break it before harm spreads.
Catalog record
| CREATOR | Xuan Zhou, Huiting Zhang, Lijie Wei, Zizhuo Wang, Shenglan Zhu, Jun Yu, Shaoshuai Wang, Wencheng Ding, Ling Feng, Jianli Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |