Engineering an immune-integrated lung-on-a-chip to reveal TOX–RAGE axis–driven fibrosis and RAGE blockade as a therapeutic strategy
Hyelim Kim, Chai Won Park, Jisun Kim, Seong-Eun Kim, June Hong Ahn, Je Kyung Seong, Wonhwa Lee, Seung-Woo Cho, Hong Nam Kim · 2025
Read Engineering an immune-integrated lung-on-a-chip to reveal TOX–RAGE axis–driven fibrosis and RAGE blockade as a therapeutic strategy by Hyelim Kim, Chai Won Park, Jisun Kim, Seong-Eun Kim, June Hong Ahn, Je Kyung Seong, Wonhwa Lee, Seung-Woo Cho, Hong Nam Kim (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12714679.txt.
Description
Hyelim Kim and co-authors build a lung on a chip to study scarring after infection in a 2025 paper. Post-infection lung fibrosis lacks good human-like models. Their chip combines vessel cells, connective cells, and macrophages in one device. A T cell factor called TOX, which rises after severe infection, was flowed through the vessel side.
The factor weakened the vessel barrier and raised a stickiness marker. Through the macrophages, it then switched the connective cells into scar builders laying down matrix. Blocking the factor's receptor beforehand protected the barrier and halted the whole chain. Mice given the same treatment survived better with less scarring. The same signature appeared in patient lung wash samples, tying the chip story to real disease.
Catalog record
| CREATOR | Hyelim Kim, Chai Won Park, Jisun Kim, Seong-Eun Kim, June Hong Ahn, Je Kyung Seong, Wonhwa Lee, Seung-Woo Cho, Hong Nam Kim |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |