Spatial patterns and prognostic relevance of CD1a+ immature and CD208+ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases

Description

Sergii Pavlov and nine co-authors charted where two kinds of dendritic cells sit inside bowel cancers and their liver spread, and whether their positions predict survival. Dendritic cells prime immune attacks, in immature and mature forms. The study covered patients whose liver tumors arrived with the primary cancer and others whose spread came later, staining tissue from healthy-looking mucosa through the tumor center and margins.

The immature cells clustered in tumor centers, while mature cells favored lymphoid patches and outer zones, a pattern suggesting cells arrive young and mature as they move outward. Densities in the primary tumor exceeded those in liver lesions for the synchronous group. High counts of one type or the other in the tumor center of liver lesions each linked to lower death risk, depending on timing. The authors say location and timing, not raw counts alone, carry the prognostic signal.

Catalog record

Source: https://europepmc.org/articles/PMC12714677