Endothelin-1 Mediates Oxaliplatin Resistance via Activation of YAP Signaling in Colorectal Cancer
Ranran Yang, Dan Yuan, Chaohan Liang, Siying Zhu, Jie Huang, Yingqi Zhang, Weiling He, Qinghai Li, Hong Zhang · 2025
Read Endothelin-1 Mediates Oxaliplatin Resistance via Activation of YAP Signaling in Colorectal Cancer by Ranran Yang, Dan Yuan, Chaohan Liang, Siying Zhu, Jie Huang, Yingqi Zhang, Weiling He, Qinghai Li, Hong Zhang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12712664.txt.
Description
Ranran Yang and co-authors show how a signaling protein helps colon cancer resist a key chemotherapy drug, in a research paper from 2025. The drug oxaliplatin anchors colon cancer care, but tumors often learn to withstand it. The protein, called endothelin-1, had been tied to drug resistance in other cancers.
The team checked public gene data and found the protein raised in colon tumors, tied to worse outcomes. Lab tests that lowered or raised its levels shifted drug response in matching ways. The protein works by switching on the YAP growth path. Blocking the protein restored drug effect in mouse tumors, marking it as a treatment target.
Catalog record
| CREATOR | Ranran Yang, Dan Yuan, Chaohan Liang, Siying Zhu, Jie Huang, Yingqi Zhang, Weiling He, Qinghai Li, Hong Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |