Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells
Lili Xiao, Jianju Liu, Yi Chen, Liang Xia, Yumeng Jiang, Xiaoyan Chen, Tianjiao Zhou, Yan Sun, Wen Lu, Hui Wang, Jian Wang, Yanmei Feng, Zhen Zhang, Shankai Yin · 2025
Read Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells by Lili Xiao, Jianju Liu, Yi Chen, Liang Xia, Yumeng Jiang, Xiaoyan Chen, Tianjiao Zhou, Yan Sun, Wen Lu, Hui Wang, Jian Wang, Yanmei Feng, Zhen Zhang, Shankai Yin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12712061.txt.
Description
Lili Xiao and co-authors reveal a two-cell loop behind noise induced hearing loss in a 2025 paper. Blame usually falls on direct harm to hair cells, the ear's sound sensors. Their work shows supporting cells next door drive much of the damage. Noise stress in hair cells switches on a growth receptor in supporting cells, which then cleaves a pore protein called Gasdermin D.
That activation fires back, worsening oxidative harm in the hair cells, they find. A harmful feedback loop forms between the two cell types. Blocking the loop's protein may protect hearing, the authors argue. The finding reframes noise damage as a team failure, not a lone cell one.
Catalog record
| CREATOR | Lili Xiao, Jianju Liu, Yi Chen, Liang Xia, Yumeng Jiang, Xiaoyan Chen, Tianjiao Zhou, Yan Sun, Wen Lu, Hui Wang, Jian Wang, Yanmei Feng, Zhen Zhang, Shankai Yin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |