Viral correlates of protection and the multifarious interactions of B and T cells

H Cody Meissner, Peter B Gilbert, Derek Eisnor, Daniel N Wolfe · 2025

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Description

Knowing what shields a person from a virus is key to judging vaccines, yet the shield has two arms that work as one. Cody Meissner and three co-authors survey that problem in 2025. One arm makes antibodies that block the virus, and blood levels of those are easy to read.

The other arm runs through T cells, whose work is far harder to assay. So most of what is known about protection rests on antibody counts, which leaves the cell arm in shadow. The right shield also shifts by virus and by the door it uses to enter the body. The authors list the many factors that muddy the cell side of the story. Their aim is a fuller account of who is safe, and why, after illness or a shot.

Catalog record

CREATORH Cody Meissner, Peter B Gilbert, Derek Eisnor, Daniel N Wolfe
YEAR2025
COLLECTIONPAPERS
FORMATTXT
FILE SIZE18 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC12710880

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