A clustering-stratified cross-validation framework for validating omics survival models: application to head and neck cancer
Antoine Dubray-Vautrin, Olivier Choussy, Constance Lamy, Grégoire Marret, Joey Martin, Jerzy Klijanienko, Sophie Vacher, Ladidi Ahmanache, Ivan Bieche, Célia Dupain, Christophe Le Tourneau, Jimmy Mullaert · 2025
Read A clustering-stratified cross-validation framework for validating omics survival models: application to head and neck cancer by Antoine Dubray-Vautrin, Olivier Choussy, Constance Lamy, Grégoire Marret, Joey Martin, Jerzy Klijanienko, Sophie Vacher, Ladidi Ahmanache, Ivan Bieche, Célia Dupain, Christophe Le Tourneau, Jimmy Mullaert (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12709853.txt.
Description
Antoine Dubray-Vautrin and co-authors test ways to check survival models built from gene data in a 2025 paper. Such models aim to foretell how long head and neck cancer patients will live. With far more gene measures than patients, the models can look strong by chance unless checks are strict.
The team used two patient sets with 581 people in all. They split the checks so that like gene groups stayed spread across the folds, a trick meant to cut bias and wobble. Three model types were run through five check plans. The grouped plan gave steadier scores with no false boost in grades. That makes it a safer base for gene-based outlook tools.
Catalog record
| CREATOR | Antoine Dubray-Vautrin, Olivier Choussy, Constance Lamy, Grégoire Marret, Joey Martin, Jerzy Klijanienko, Sophie Vacher, Ladidi Ahmanache, Ivan Bieche, Célia Dupain, Christophe Le Tourneau, Jimmy Mullaert |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |