Very low energy ketogenic therapy: an anti-inflammatory medical nutritional approach for MASLD in obesity
Luigi Barrea, Ludovica Verde, Martina Galasso, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri · 2025
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Description
Luigi Barrea and co-authors tested a very low calorie ketogenic diet in women with obesity and a fatty liver disease, in a study published in 2025. The disease, tied to poor metabolic health, often travels with long-term inflammation. The diet phase studied supplies under eight hundred calories a day, mostly from protein and fat. Eighty women with an average age near thirty-nine took part at a Naples hospital.
After the diet phase, weight, waist size, and body fat all fell clearly. Liver enzyme levels, blood fats, blood sugar, and a key inflammation marker also dropped. Weight loss tracked with drops in fat mass and several blood measures. Change in the inflammation marker proved the strongest predictor of liver improvement, accounting for about two-thirds of the change. The authors credit the diet's calming effect on inflammation.
Catalog record
| CREATOR | Luigi Barrea, Ludovica Verde, Martina Galasso, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |