Automated GMP-compatible production of universal CAR Tregs for organ-targeted tolerance induction
Kavitha Lakshmi, Alexandra von Jutrzenka-Trzebiatowski, Liliana Loureiro, Karla Elizabeth González Soto, Katja Peter, José Manuel Marín Morales, Samikshya Santosh Nirmala, Nicole Berndt, Claudia Arndt, Yueyuan Hu, Jing-Wun Li, Claudia Peitzsch, Anna Taubenberger, Rebekka Wehner, Marc Schmitz, Kristi · 2025
Read Automated GMP-compatible production of universal CAR Tregs for organ-targeted tolerance induction by Kavitha Lakshmi, Alexandra von Jutrzenka-Trzebiatowski, Liliana Loureiro, Karla Elizabeth González Soto, Katja Peter, José Manuel Marín Morales, Samikshya Santosh Nirmala, Nicole Berndt, Claudia Arndt, Yueyuan Hu, Jing-Wun Li, Claudia Peitzsch, Anna Taubenberger, Rebekka Wehner, Marc Schmitz, Kristi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12709696.txt.
Description
Kavitha Lakshmi and co-authors build a factory process for universal engineered immune cells in a 2025 paper. Regulatory T cells can teach the body to tolerate a graft or calm inflammation, and lab trials show early promise. Aiming those cells with a chimeric antigen receptor sharpens their local effect, but custom batches cost too much and aim at one target only.
Their answer is an adapter system. The cells carry a receptor with no target of its own, and a separate module plugs in the aim, swap by swap. A module aimed at a gut-rich marker served as the proof case, for calming gut graft-versus-host disease. The full run, from blood draw to expanded cells, was automated on clinical machines under good manufacturing practice rules. The authors pitch the platform as clinic-ready.
Catalog record
| CREATOR | Kavitha Lakshmi, Alexandra von Jutrzenka-Trzebiatowski, Liliana Loureiro, Karla Elizabeth González Soto, Katja Peter, José Manuel Marín Morales, Samikshya Santosh Nirmala, Nicole Berndt, Claudia Arndt, Yueyuan Hu, Jing-Wun Li, Claudia Peitzsch, Anna Taubenberger, Rebekka Wehner, Marc Schmitz, Kristi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |