Cost-effectiveness of intradiscal injection with condoliase versus microendoscopic discectomy for lumbar disc herniation: a retrospective multicenter study
Takuya Takahashi, Hiroyuki Sato, Yohei Takahashi, Kota Watanabe, Tomohiro Banno, Kyohei Sakaki, Yoshiyasu Arai, Yuichi Takano, Yawara Eguchi, Yuki Taniguchi, Satoshi Maki, Yasuchika Aoki, Toshitaka Yoshii, Hiroshi Yamada, Takashi Kaito, Yutaka Hiraizumi, Masatune Yamagata, Masaya Nakamura, Naobumi H · 2025
Read Cost-effectiveness of intradiscal injection with condoliase versus microendoscopic discectomy for lumbar disc herniation: a retrospective multicenter study by Takuya Takahashi, Hiroyuki Sato, Yohei Takahashi, Kota Watanabe, Tomohiro Banno, Kyohei Sakaki, Yoshiyasu Arai, Yuichi Takano, Yawara Eguchi, Yuki Taniguchi, Satoshi Maki, Yasuchika Aoki, Toshitaka Yoshii, Hiroshi Yamada, Takashi Kaito, Yutaka Hiraizumi, Masatune Yamagata, Masaya Nakamura, Naobumi H (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12708873.txt.
Description
Takuya Takahashi and a large team of co-authors published this 2025 study comparing the value of two treatments for a slipped lumbar disc in Japan. One option injects an enzyme, condoliase, into the disc to shrink it; the other is keyhole surgery to remove the bulge. The injection costs far less up front, but value over time needed proof.
Nine centers contributed 229 injection patients and 98 surgery patients, all with the same herniation type on scans. A Markov model rolled costs and quality-adjusted life years forward. The injection matched surgery on health outcomes at clearly lower direct cost, a pattern that held under stress tests of the assumptions. The authors present the injection as the better buy for suitable patients.
Catalog record
| CREATOR | Takuya Takahashi, Hiroyuki Sato, Yohei Takahashi, Kota Watanabe, Tomohiro Banno, Kyohei Sakaki, Yoshiyasu Arai, Yuichi Takano, Yawara Eguchi, Yuki Taniguchi, Satoshi Maki, Yasuchika Aoki, Toshitaka Yoshii, Hiroshi Yamada, Takashi Kaito, Yutaka Hiraizumi, Masatune Yamagata, Masaya Nakamura, Naobumi H |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |