Mitochondrial dysfunction in cellular senescence: a bridge to neurodegenerative disease
Adam J. Hruby, Ryo Higuchi-Sanabria · 2025
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Description
Adam Hruby and Ryo Higuchi-Sanabria review how failing mitochondria, the cell's power plants, drive cell ageing in a 2025 paper. Aged cells stop dividing for good and pump out signals that stir swelling in nearby tissue. Such cells build up with age and are blamed for much age linked decline.
The review walks through what goes wrong: weaker energy output, poor calcium handling, odd waste products, and lax quality control. Each flaw helps lock a cell into the aged state and feed its signal mix. The authors then link aged cells to brain diseases such as Alzheimer's. Their claim is that broken power plants form the bridge between the two.
Catalog record
| CREATOR | Adam J. Hruby, Ryo Higuchi-Sanabria |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |