Ferroptosis and autophagy-related genes contribute to hypertrophic cardiomyopathy progression
Aiai Zhang, Wei Liu, Meiling Du, Feixing Li, Mengyang Yi, Huixian Li, Zhiwei Yang, Fangjiang Li · 2025
Read Ferroptosis and autophagy-related genes contribute to hypertrophic cardiomyopathy progression by Aiai Zhang, Wei Liu, Meiling Du, Feixing Li, Mengyang Yi, Huixian Li, Zhiwei Yang, Fangjiang Li (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12708844.txt.
Description
Aiai Zhang and co-authors search for gene targets tied to a thickened heart muscle disease in a 2025 study. The disease, hypertrophic cardiomyopathy, can worsen over time, and two cell processes, an iron driven cell death called ferroptosis and the self recycling process called autophagy, may drive that course. The team mined a public gene data set and two process databases for genes that changed in the disease.
Dozens of changed genes overlapped the two processes, clustering in pathways for cell recycling, cell death, and antioxidant activity. Ten hub genes emerged from a protein interaction network. Single cell data showed those hubs highly active in macrophages in human and diseased hearts, marking them as candidate drug and diagnosis targets.
Catalog record
| CREATOR | Aiai Zhang, Wei Liu, Meiling Du, Feixing Li, Mengyang Yi, Huixian Li, Zhiwei Yang, Fangjiang Li |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |