Rapid imaging of pulmonary metastasis from colorectal cancer with a red fluorescence probe targeting puromycin-sensitive aminopeptidase and dipeptidyl peptidase IV
Kimihiko Kobayashi, Kyohhei Fujita, Ryosuke Kojima, Rumi Hino, Yasuteru Urano, Masaaki Sato · 2025
Read Rapid imaging of pulmonary metastasis from colorectal cancer with a red fluorescence probe targeting puromycin-sensitive aminopeptidase and dipeptidyl peptidase IV by Kimihiko Kobayashi, Kyohhei Fujita, Ryosuke Kojima, Rumi Hino, Yasuteru Urano, Masaaki Sato (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12708840.txt.
Description
Kimihiko Kobayashi and co-authors wrote a study from 2025 on a glowing dye that can show lung spread of bowel cancer during surgery. When bowel cancer spreads to the lung, surgeons cut out the spots with a rim of sound tissue. Missed cancer at the rim can let the disease return. A dye that lights up the spots fast could guide the cut.
The team screened a library of dyes that wake when cut by enzymes. One dye lit up in rectal spread tissue, woken by a named enzyme. An older red dye of that kind found most rectal spreads and all colon spreads, with few false alarms. Blocking tests and stains confirmed it answers to two enzymes. On cut samples, it drew the spread's edge fast. The team calls it a strong tool for the operating room.
Catalog record
| CREATOR | Kimihiko Kobayashi, Kyohhei Fujita, Ryosuke Kojima, Rumi Hino, Yasuteru Urano, Masaaki Sato |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |