Altered cortical gyrification as a marker of treatment resistance in patients with first-episode psychosis
Moonyoung Jang, Inkyung Park, Minah Kim, Sunghyun Park, Jun Soo Kwon · 2025
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Description
Moonyoung Jang and co-authors published a 2025 study of the folding pattern of the cortex, the outer layer of the brain. They test it as a marker of who will resist treatment in a first episode of psychosis. Failed treatment costs patients and the health budget alike. No marker now predicts who will not benefit from the drugs. The hope of the team is the folding pattern, set early in life.
Brain scans came from over a hundred first-episode patients and as many healthy peers, at first contact with care. The patients were then followed in ordinary clinic life, and their end state was classified as resistant or responsive. The patient group showed reduced folding in three zones. The reduced zones of the subgroups sat in distinct places. Once drug dose was taken into account, one zone separated them. The team reads the patterns as signs of distinct roots.
Catalog record
| CREATOR | Moonyoung Jang, Inkyung Park, Minah Kim, Sunghyun Park, Jun Soo Kwon |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |