Adenosine in human atrial fibrillation modulates and re-distributes atria-wide dominant frequencies and directs to reentry ablation sites with improved outcome
David Calvo, Lucia Salinas, Pablo Martínez-Camblor, María Salgado, Ruth Álvarez-Velasco, Amaia Martínez-León, Minel Soroa, Daniel García-Iglesias, David Filgueiras-Rama, Juan José Gonzalez-Ferrer, Victoria Cañadas, Ricardo Salgado, Alba Cruz, Jorge Quintanilla, Andrés Redondo, Miguel Rodrigo, Julián · 2025
Read Adenosine in human atrial fibrillation modulates and re-distributes atria-wide dominant frequencies and directs to reentry ablation sites with improved outcome by David Calvo, Lucia Salinas, Pablo Martínez-Camblor, María Salgado, Ruth Álvarez-Velasco, Amaia Martínez-León, Minel Soroa, Daniel García-Iglesias, David Filgueiras-Rama, Juan José Gonzalez-Ferrer, Victoria Cañadas, Ricardo Salgado, Alba Cruz, Jorge Quintanilla, Andrés Redondo, Miguel Rodrigo, Julián (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12708623.txt.
Description
David Calvo and a large team of co-authors studied 25 patients with persistent atrial fibrillation in a 2025 report. Atrial fibrillation is a common heart rhythm disorder. The team gave patients adenosine, a drug known to accelerate the rotational activity thought to drive the disorder. They mapped electrical activity across the atria from outside the body, twice at baseline and again at the peak effect of a 12 mg dose.
Adenosine changed the distribution of dominant frequencies across the atria in an uneven way. The authors built a new measure, the DF Stability Index, which combines how much a site's frequency rose with how stable that site was. Patients in whom all high-index regions were ablated were more often free of arrhythmia on follow-up. The authors propose the index as a physiological guide for ablation treatment.
Catalog record
| CREATOR | David Calvo, Lucia Salinas, Pablo Martínez-Camblor, María Salgado, Ruth Álvarez-Velasco, Amaia Martínez-León, Minel Soroa, Daniel García-Iglesias, David Filgueiras-Rama, Juan José Gonzalez-Ferrer, Victoria Cañadas, Ricardo Salgado, Alba Cruz, Jorge Quintanilla, Andrés Redondo, Miguel Rodrigo, Julián |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |