Evaluation of T-NGS, Xpert Ultra, and Line Probe Assay on Clinical Samples for the Diagnosis of Drug-Resistant Pulmonary Tuberculosis in Rio de Janeiro
Marcela Bhering, Eunice Petris Ribeiro, Anna Karla Silveira, Carolyne Lalucha, Elizabete Oliveira Ribeiro, Tathiany Igreja, Luís Cristóvão Pôrto, Danielle Secco, Pedro Eduardo Almeida da Silva, Miguel Viveiros, Martha Oliveira, Afrânio Kritski · 2025
Read Evaluation of T-NGS, Xpert Ultra, and Line Probe Assay on Clinical Samples for the Diagnosis of Drug-Resistant Pulmonary Tuberculosis in Rio de Janeiro by Marcela Bhering, Eunice Petris Ribeiro, Anna Karla Silveira, Carolyne Lalucha, Elizabete Oliveira Ribeiro, Tathiany Igreja, Luís Cristóvão Pôrto, Danielle Secco, Pedro Eduardo Almeida da Silva, Miguel Viveiros, Martha Oliveira, Afrânio Kritski (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12707747.txt.
Description
Fast proof of drug resistance guides tuberculosis care, but no single test catches every resistant strain. Marcela Bhering and co-authors compared three rapid tests on samples from forty suspected drug-resistant lung cases in Rio de Janeiro. Cases came from twenty eighteen to twenty twenty-two. Lab-grown drug testing served as the standard, and a deeper gene reading method settled disagreements.
Two rapid tests caught rifampicin resistance in about nine of ten cases. One test missed more isoniazid resistance, and it weakened when samples held few bacteria. The deep reading found resistance the other tests missed, plus mixed infections in some samples. The authors back layered testing where resistance is common. Their counts show where each tool earns its place.
Catalog record
| CREATOR | Marcela Bhering, Eunice Petris Ribeiro, Anna Karla Silveira, Carolyne Lalucha, Elizabete Oliveira Ribeiro, Tathiany Igreja, Luís Cristóvão Pôrto, Danielle Secco, Pedro Eduardo Almeida da Silva, Miguel Viveiros, Martha Oliveira, Afrânio Kritski |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |