Prevalence of dual-donating amines in key regions of functional RNAs
Andrew J Veenis, Md Sharear Saon, Philip C Bevilacqua · 2026
Read Prevalence of dual-donating amines in key regions of functional RNAs by Andrew J Veenis, Md Sharear Saon, Philip C Bevilacqua (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12707130.txt.
Description
Andrew Veenis and co-authors map a special hydrogen bond pattern inside RNA in this study, published in 2025. RNA does many key jobs in the cell, nearly all through folded, bonded shapes. Its building blocks have few bond donors, and only one group can donate two bonds at once.
The team built a computing workflow to mine solved RNA structures for these dual-donating amines. They checked hundreds of thousands of amines across many structures. Dual donors showed up most often on guanine bases, meeting varied partner pairs. The map shows where this rare bond type holds RNA folds together. It may guide drug and RNA design work.
Catalog record
| CREATOR | Andrew J Veenis, Md Sharear Saon, Philip C Bevilacqua |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |