Bone marrow mesenchymal stem cell-derived exosomes improve pyroptosis and mitochondrial integrity through miR-515-5p-mediated TLR4/NLRP3/GSDMD axis in rheumatoid arthritis
Dongfeng Cai, Chao Zhong, Zixiao Yang, Jimo Li, Song Hong · 2025
Read Bone marrow mesenchymal stem cell-derived exosomes improve pyroptosis and mitochondrial integrity through miR-515-5p-mediated TLR4/NLRP3/GSDMD axis in rheumatoid arthritis by Dongfeng Cai, Chao Zhong, Zixiao Yang, Jimo Li, Song Hong (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12706942.txt.
Description
Dongfeng Cai and co-authors test stem cell exosomes against joint harm in rheumatoid arthritis in a 2025 paper. Bone marrow stem cells ease this joint disease in past work. Their shed parcels, exosomes, may carry the good effect sans whole cells.
Rat stem cell exosomes were loaded with a small RNA, miR-515-5p. Joint cells lit by an immune signal served as the disease model. Loaded parcels curbed cell fire death and shielded cell power plants. Assays proved the small RNA binds a key alarm receptor. That binding quiets a three step fire path in the cells. RNA loaded parcels name a cell free care path.
Catalog record
| CREATOR | Dongfeng Cai, Chao Zhong, Zixiao Yang, Jimo Li, Song Hong |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |