Temporal transcriptomic profiling reveals distinct age-associated gene expression signatures in gonads under reduced insulin/IGF-1 signaling in Caenorhabditis elegans
Neha Kaushik, Soumya Rastogi, Shivani Kapadia, Vaibhav Jain, Sonia Verma, Deepak Pandey, Mona Sharma, Surabhi Gupta, Ashutosh Halder, Simon Gregory, Neeraj Kumar · 2025
Read Temporal transcriptomic profiling reveals distinct age-associated gene expression signatures in gonads under reduced insulin/IGF-1 signaling in Caenorhabditis elegans by Neha Kaushik, Soumya Rastogi, Shivani Kapadia, Vaibhav Jain, Sonia Verma, Deepak Pandey, Mona Sharma, Surabhi Gupta, Ashutosh Halder, Simon Gregory, Neeraj Kumar (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12706931.txt.
Description
Neha Kaushik and co-authors report a worm study, published in 2025, on how the reproductive organs age when a key hormone pathway is turned down. In the roundworm Caenorhabditis elegans, weaker insulin like signaling lengthens both life and the fertile period. The team read gene activity in dissected gonads at four adult ages, from youth to late reproductive life, in normal worms and in a long lived mutant.
Whole worm samples taken at the youngest and oldest ages allowed a direct contrast between gonad and body wide patterns. Many gene changes proved specific to the gonad rather than shared across tissues. Readers get a time resolved map of reproductive aging that separates organ level control from the general slowing of age.
Catalog record
| CREATOR | Neha Kaushik, Soumya Rastogi, Shivani Kapadia, Vaibhav Jain, Sonia Verma, Deepak Pandey, Mona Sharma, Surabhi Gupta, Ashutosh Halder, Simon Gregory, Neeraj Kumar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |