BEX2 regulates autophagy by inhibiting PIK3CA-p85 interaction in non-small-cell lung cancer cells
Yu Wang, Ning Mu, Xinke Wang, Jianhao Liu, Yiqing Qu, Xiangguo Liu, Ling Su · 2025
Read BEX2 regulates autophagy by inhibiting PIK3CA-p85 interaction in non-small-cell lung cancer cells by Yu Wang, Ning Mu, Xinke Wang, Jianhao Liu, Yiqing Qu, Xiangguo Liu, Ling Su (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12706926.txt.
Description
Yu Wang and six co-authors show how BEX2, a growth-linked protein, steers self-eating in lung cancer cells. Their paper is from two thousand twenty-five. Self-eating, or autophagy, lets tumour cells live through stress and can blunt drugs. A key growth path, PI3K to mTOR, is a prime dial for it, but BEX2's role was unclear.
A known self-eating drug lifts BEX2 in the cells. BEX2 binds the PI3K core part and blocks its join with its mate part, which dims the whole path. With that path dimmed, self-eating flux rises. The chain ties BEX2 to cell clean-up through one named contact, a point that rests on the core part's presence.
Catalog record
| CREATOR | Yu Wang, Ning Mu, Xinke Wang, Jianhao Liu, Yiqing Qu, Xiangguo Liu, Ling Su |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |