Deciphering the pharmacological mechanisms of salidroside in cervical cancer by combining network pharmacology, molecular docking, and in vitro studies
Jianmin Wang, Guanghui Song, Liaqat Hussain, Lili Xing · 2025
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Description
A natural compound from a hardy plant shows promise against cervical cancer, but its exact targets in cancer cells were unclear. Jianmin Wang and co-authors combined computer modeling with lab tests to map those targets in this 2025 study. They drew cancer gene data from large public databases.
Network methods linked the compound to a set of genes and pathways tied to the cancer. Computer docking then checked how well the compound fits the key proteins from that set. Lab tests on cells were used to confirm the main predictions. This three-part approach is now common for natural products, since it narrows hundreds of possible targets to a testable few. The work is early and cell-based, so patient benefit remains unproven.
Catalog record
| CREATOR | Jianmin Wang, Guanghui Song, Liaqat Hussain, Lili Xing |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |