miRNA Biomarkers Diagnose Amyotrophic Lateral Sclerosis in Circulating Blood
Rachael Anne Dunlop, Paul Alan Cox, Paul Mehta, Elijah W. Stommel, Sandra Anne Banack · 2025
Read miRNA Biomarkers Diagnose Amyotrophic Lateral Sclerosis in Circulating Blood by Rachael Anne Dunlop, Paul Alan Cox, Paul Mehta, Elijah W. Stommel, Sandra Anne Banack (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12705848.txt.
Description
Rachael Dunlop and co-authors validate a blood test that reads eight small RNAs to diagnose ALS, a disease now confirmed only after long clinical detective work. Diagnostic delay costs patients time in a fast disease. Their 2025 study extracts the microRNA panel from blood plasma and measures it with standard PCR chemistry.
Cutoffs were fixed in an earlier sample set, then applied untouched to fresh cohorts totaling nearly eight hundred samples. The test separated ALS from controls with high sensitivity and specificity, and the RNA shifts matched the earlier findings. Streamlined handling cut the assay's time and cost as well. Neurologists get a candidate for the blood-based ALS test the field has wanted for decades.
Catalog record
| CREATOR | Rachael Anne Dunlop, Paul Alan Cox, Paul Mehta, Elijah W. Stommel, Sandra Anne Banack |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |