Hsa_circ_0000437 promotes the progression of rheumatic valvular heart disease by activating the mitogen-activated protein kinase signaling pathways after sponging let-7f-5p and targeting RAS-like proto-oncogene B
Linwen Zhu, Ni Li, Huoshun Shi, Jie Song, Zhongjie Fang, Qinbo Shen, Xiuying Zhu, Yanggang Dan, Guofeng Shao, Lebo Sun · 2025
Read Hsa_circ_0000437 promotes the progression of rheumatic valvular heart disease by activating the mitogen-activated protein kinase signaling pathways after sponging let-7f-5p and targeting RAS-like proto-oncogene B by Linwen Zhu, Ni Li, Huoshun Shi, Jie Song, Zhongjie Fang, Qinbo Shen, Xiuying Zhu, Yanggang Dan, Guofeng Shao, Lebo Sun (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12705832.txt.
Description
Linwen Zhu and co-authors trace a circular RNA that drives a heart valve disease in this 2025 study. The disease scars and thickens the valves after rheumatic illness. Circular RNAs are ring-shaped RNA pieces that can soak up smaller RNAs, freeing other genes from their control.
From patient samples, the team found one ring RNA at high levels, tied to low levels of a small RNA it can soak up. In valve cells, the ring RNA sped growth and movement, and the small RNA eased those effects. The ring's target protein feeds a signal path linked to swelling. The authors map this three-part chain as a clue to how the disease worsens.
Catalog record
| CREATOR | Linwen Zhu, Ni Li, Huoshun Shi, Jie Song, Zhongjie Fang, Qinbo Shen, Xiuying Zhu, Yanggang Dan, Guofeng Shao, Lebo Sun |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |