Shedding light on the dynamic interplay of positive and negative symptoms of psychosis with Behavioral Tractography
Andrea Imparato, Natacha Reich, Clémence Feller, Laura Ilen, Stephan Eliez, Christopher Graser, Maude Schneider, Corrado Sandini · 2025
Read Shedding light on the dynamic interplay of positive and negative symptoms of psychosis with Behavioral Tractography by Andrea Imparato, Natacha Reich, Clémence Feller, Laura Ilen, Stephan Eliez, Christopher Graser, Maude Schneider, Corrado Sandini (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12705817.txt.
Description
Andrea Imparato and co-authors study how positive and negative symptoms of psychosis interact over time, using phone-based momentary tracking. Standard interviews look backward and miss short-term shifts in symptoms and context. The team applies a method called Behavioral Tractography to people with 22q11.2 deletion syndrome, a group at high risk for psychosis. Momentary assessments record symptoms in real life, many times over days.
After reducing the network's complexity, the authors find that the momentary patterns mirror the symptom structure from gold-standard interviews. This suggests shared mechanisms and supports the tracking method as valid. The approach also dissects how psychotic symptoms and motivational deficits influence each other, shaped by overall severity. It separates patients with mostly positive profiles from those with mostly negative ones. Vulnerability to later effects varies apart from average symptom level, adding value beyond standard assessment.
Catalog record
| CREATOR | Andrea Imparato, Natacha Reich, Clémence Feller, Laura Ilen, Stephan Eliez, Christopher Graser, Maude Schneider, Corrado Sandini |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 100 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |