Urine-Derived CD105-Positive Exosome Promotes Macrophage M1 Polarization Through the TGF-β1/Smad3 Signaling Axis To Exacerbate Lupus Nephritis
Yanmin Pang, Xiuhong Pan, Linlin He, Yao Zuo, Xiaochao Wang, Yanwu You · 2025
Read Urine-Derived CD105-Positive Exosome Promotes Macrophage M1 Polarization Through the TGF-β1/Smad3 Signaling Axis To Exacerbate Lupus Nephritis by Yanmin Pang, Xiuhong Pan, Linlin He, Yao Zuo, Xiaochao Wang, Yanwu You (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12705812.txt.
Description
Yanmin Pang and co-authors study in 2025 how tiny packets shed into urine worsen kidney damage in lupus, an immune disease. The packets carry a protein on their surface. In samples from 20 patients with lupus kidney disease, that protein was high in kidney tissue and in the urine packets.
The team split the packets from urine and tested them on immune cells in dishes. Packets with extra surface protein pushed the cells toward an attacking state. Cuts in the protein had the reverse effect. A known signal pathway in the cells carried the effect, since drugs that block or boost that pathway flipped the result. Tests in animals backed the dish work. The findings name a packet and protein that could serve as a sign of disease activity or a target for new drugs.
Catalog record
| CREATOR | Yanmin Pang, Xiuhong Pan, Linlin He, Yao Zuo, Xiaochao Wang, Yanwu You |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |