Mitochondrial RNA cytosolic leakage drives the SASP
Stella Victorelli, Madeline Eppard, Hélène Martini, Seung-Hwa Woo, Stacia P. A. Everts, Gung Lee, Nicholas Pirius, Nuan Han, Eugene Y. Liang, Ana Catarina Franco, Yeaeun Han, Dominik Saul, Eva Nóvoa, Rubén Nogueiras, Patrick L. Splinter, Steven P. O’Hara, Olivia Morgenthaler, Lucía Valenzuela-Pérez, · 2025
Read Mitochondrial RNA cytosolic leakage drives the SASP by Stella Victorelli, Madeline Eppard, Hélène Martini, Seung-Hwa Woo, Stacia P. A. Everts, Gung Lee, Nicholas Pirius, Nuan Han, Eugene Y. Liang, Ana Catarina Franco, Yeaeun Han, Dominik Saul, Eva Nóvoa, Rubén Nogueiras, Patrick L. Splinter, Steven P. O’Hara, Olivia Morgenthaler, Lucía Valenzuela-Pérez, (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12705736.txt.
Description
Stella Victorelli and co-authors show that aging cells leak a second kind of genetic material that fans their inflammatory output. Senescent cells, which have stopped dividing, broadcast a cocktail of inflammatory signals called the SASP that damages tissue and drives aging. Leaked mitochondrial DNA was already known to feed it through an internal alarm pathway. The team now implicates mitochondrial RNA as well.
In senescent cells the RNA built up in the cell's main compartment, where it tripped two RNA sensors, RIG-I and MDA5. They triggered a signaling hub that switched the inflammatory program on. Blocking them cut the secreted factors sharply. Two pore proteins, BAX and BAK, were the leak route: deleting them reduced the inflammatory output in dishes and in a mouse model of fatty liver disease. The authors flag the leaked RNA as a possible drug target against age-related inflammation.
Catalog record
| CREATOR | Stella Victorelli, Madeline Eppard, Hélène Martini, Seung-Hwa Woo, Stacia P. A. Everts, Gung Lee, Nicholas Pirius, Nuan Han, Eugene Y. Liang, Ana Catarina Franco, Yeaeun Han, Dominik Saul, Eva Nóvoa, Rubén Nogueiras, Patrick L. Splinter, Steven P. O’Hara, Olivia Morgenthaler, Lucía Valenzuela-Pérez, |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |