Nucleosome assembly protein-like 1 degradation-dependent novel cardioprotection mechanism of Wnt2 against ischemia‒reperfusion injury
Ying Wang, Liming Chen, Jinyi Lin, Xi Liu, Kejia Jin, Chenxing Huang, Hao Wang, Jianguo Jia, Jian Wu, Zhiwen Ding, Pan Gao, Junbo Ge, Hui Gong, Yunzeng Zou · 2025
Read Nucleosome assembly protein-like 1 degradation-dependent novel cardioprotection mechanism of Wnt2 against ischemia‒reperfusion injury by Ying Wang, Liming Chen, Jinyi Lin, Xi Liu, Kejia Jin, Chenxing Huang, Hao Wang, Jianguo Jia, Jian Wu, Zhiwen Ding, Pan Gao, Junbo Ge, Hui Gong, Yunzeng Zou (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12705695.txt.
Description
Ying Wang and a large team uncover how a signaling protein protects the heart during restored blood flow after a heart attack. Their study was published in twenty twenty-five. Reopening the artery saves muscle but the returning flow itself injures tissue.
Blood levels of the protein, Wnt2, fell in patients after reperfusion, and lower levels meant worse injury markers. Giving the protein to mice eased damage and improved heart function. It worked by removing a partner protein that had been silencing antioxidant genes. With that brake degraded, defense genes switched back on, cell death dropped, and removing the partner alone mimicked the benefit. The pathway offers a drug target for reperfusion injury.
Catalog record
| CREATOR | Ying Wang, Liming Chen, Jinyi Lin, Xi Liu, Kejia Jin, Chenxing Huang, Hao Wang, Jianguo Jia, Jian Wu, Zhiwen Ding, Pan Gao, Junbo Ge, Hui Gong, Yunzeng Zou |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |