Early changes in the properties of CA3 engram cells explored with a novel viral tool in mice
Dario Cupolillo, Noelle Grosjean, Catherine Marneffe, Julio Viotti, Celia Reynaud, Severine Deforges, Mario Carta, Christophe Mulle, Katalin Toth, Dario Cupolillo, Noelle Grosjean, Catherine Marneffe, Julio Viotti, Celia Reynaud, Severine Deforges, Mario Carta, Christophe Mulle · 2025
Read Early changes in the properties of CA3 engram cells explored with a novel viral tool in mice by Dario Cupolillo, Noelle Grosjean, Catherine Marneffe, Julio Viotti, Celia Reynaud, Severine Deforges, Mario Carta, Christophe Mulle, Katalin Toth, Dario Cupolillo, Noelle Grosjean, Catherine Marneffe, Julio Viotti, Celia Reynaud, Severine Deforges, Mario Carta, Christophe Mulle (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12705066.txt.
Description
Dario Cupolillo and co-authors use a new viral tool to catch memory cells in the act of forming. Their 2025 study works in the mouse hippocampus, where small groups of neurons, called engram cells, are thought to hold a memory. The tool tags active cells with a fast-fading glow within hours of a single learning trial, far quicker than older markers.
With that early window, the team measured the electrical traits of tagged cells in the CA3 region just after learning. A second, slower system tagged cells a day later for comparison. Watching the engram at both ages shows how a fresh memory's cells differ from a settled one.
Catalog record
| CREATOR | Dario Cupolillo, Noelle Grosjean, Catherine Marneffe, Julio Viotti, Celia Reynaud, Severine Deforges, Mario Carta, Christophe Mulle, Katalin Toth, Dario Cupolillo, Noelle Grosjean, Catherine Marneffe, Julio Viotti, Celia Reynaud, Severine Deforges, Mario Carta, Christophe Mulle |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |