In vivo Testing of Nanotherapeutics for Osteosarcoma Treatment: Translational Challenges and Solutions
Gabriele D’Anna, Endris Yibru Hanurry, Anna Piperno, Angela Scala · 2025
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Description
Gabriele D'Anna and co-authors review in 2025 live-animal testing of nano drugs for osteosarcoma, a bone cancer of youth. The cancer spreads early, above all to the lungs, and standard drug mixes have barely changed in forty years. Nano carriers promise targeted delivery with less harm, yet most stay at lab stage.
The review sorts a decade of animal studies on smart carriers for chemo, immune, and gene routes. Gains span longer blood life, better tumor build-up, and slower clearance. Blocks span scale-up, safety proof, and the gap from mouse tumors to human disease. Fixes for those blocks close the survey.
Catalog record
| CREATOR | Gabriele D’Anna, Endris Yibru Hanurry, Anna Piperno, Angela Scala |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 116 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |