LBX2-AS1 in acceleration of glycolysis and cancer angiogenesis via miR-491-5p/MDK signaling axis in colorectal cancer: an experimental study
Juan Wang, Chao Li, Guanghai Wu, Jing Xu · 2025
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Description
Juan Wang and co-authors finger a long non-coding RNA that fuels colorectal cancer's sugar burning and blood vessel growth, in this 2025 study. The RNA, LBX2-AS1, runs high in tumors and marks poor prognosis. Silencing it in cancer cells slowed their growth, movement, and invasion, and cut their glucose use and vessel-growth signals.
A partner protein, midkine, reversed all those effects when restored, and silencing the RNA also shrank tumors in mice. The chain runs through a small RNA the long RNA sponges up. The authors propose the axis as a diagnostic marker and drug target.
Catalog record
| CREATOR | Juan Wang, Chao Li, Guanghai Wu, Jing Xu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |