A genome-wide association study reveals additive and recessive alleles affecting male fertility in pigs
Pedro Sá, Marta Gòdia, Rodrigo M. Godinho, Claudia A. Sevillano, Barbara Harlizius, Ole Madsen, Henk Bovenhuis · 2025
Read A genome-wide association study reveals additive and recessive alleles affecting male fertility in pigs by Pedro Sá, Marta Gòdia, Rodrigo M. Godinho, Claudia A. Sevillano, Barbara Harlizius, Ole Madsen, Henk Bovenhuis (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12703936.txt.
Description
Sá leads a team scanning pig genomes for variants that shape male fertility in a 2025 paper. Commercial pig lines record semen traits at industrial scale, making them a strong model. Hundreds of thousands of ejaculate records from thousands of boars were analyzed.
Ten genomic regions stood out across fifteen semen traits. Four held recessive harmful alleles, and some markers affected several traits at once. Whole-genome data pointed to missense changes in genes tied to sperm production. Oddly, some harmful allele frequencies rose over recent years despite culling. The authors say breeders can now select against the worst alleles. The findings also inform mammalian fertility genetics generally. Routine industry data powered the discovery.
Catalog record
| CREATOR | Pedro Sá, Marta Gòdia, Rodrigo M. Godinho, Claudia A. Sevillano, Barbara Harlizius, Ole Madsen, Henk Bovenhuis |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |