Pharmacological Mechanisms of CheReCunJin Formula in Ameliorating Sjögren’s Syndrome: Suppression of IL-17 Signal-Mediated Inflammatory Cascade
Yu Gan, Lijing Du, Yuanfang Sun, Fugen Li, Haoran Chen, Shikai Yan, Xue Xiao, Shasha Li, Bin Wu · 2025
Read Pharmacological Mechanisms of CheReCunJin Formula in Ameliorating Sjögren’s Syndrome: Suppression of IL-17 Signal-Mediated Inflammatory Cascade by Yu Gan, Lijing Du, Yuanfang Sun, Fugen Li, Haoran Chen, Shikai Yan, Xue Xiao, Shasha Li, Bin Wu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12702288.txt.
Description
Sjögren's syndrome dries the eyes and mouth by attacking the glands, and China counts it as its second most common autoimmune disease, still without an effective therapy. Nine researchers examine a traditional formula called CheReCunJin in 2025. They identify 373 compounds in the mix, then use network analysis and docking simulations to predict its working parts. A mouse strain that develops the disease on its own tests the formula in the body.
Treated mice produced more saliva, drank less desperately, and showed less gland damage. Blood markers of immune attack fell. Deeper checks point to one route: the formula calms Th17 cells and the IL-17 signal they drive. The authors credit a handful of named plant compounds for the effect.
Catalog record
| CREATOR | Yu Gan, Lijing Du, Yuanfang Sun, Fugen Li, Haoran Chen, Shikai Yan, Xue Xiao, Shasha Li, Bin Wu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |