Pentatrichomonas hominis Infection Induces Chronic Intestinal Inflammation in Immunocompetent Mice
Yao Rong, Yidan Cheng, Hongbo Zhang, Xichen Zhang, Yu Zheng, Jianhua Li, Pengtao Gong, Xiaocen Wang, Xin Li, Nan Zhang · 2025
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Description
Yao Rong, Yidan Cheng, Hongbo Zhang, and a wider team wrote this research paper, published in 2025. It shows that a gut protozoan long dismissed as a harmless tenant can cause lasting intestinal inflammation even in mice with fully healthy immune systems.
Pentatrichomonas hominis turns up in human and animal diarrhea cases as the only suspect, yet textbooks call it a commensal. The team infected healthy laboratory mice and watched for ninety days. The large intestine showed invading immune cells, dying surface cells, and sloughing lining, and the damage deepened over time. Mucus cells faltered: staining rose while output of the key mucus protein fell. Inflammatory signals climbed in gut fluid and blood. The gut's bacterial community shifted, gaining diversity and more of an inflammation-linked genus while losing helpful species. The authors call the parasite a neglected zoonotic threat.
Catalog record
| CREATOR | Yao Rong, Yidan Cheng, Hongbo Zhang, Xichen Zhang, Yu Zheng, Jianhua Li, Pengtao Gong, Xiaocen Wang, Xin Li, Nan Zhang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |