A prospective observational study of pancreatic cancer risk in men and women with pathogenic variants in BRCA1 or BRCA2
Eli Marie Grindedal, Manuela Zucknick, Sigrid Tronsli Hovland, Tom K Grimsrud, Lovise Mæhle · 2025
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Description
Eli Marie Grindedal and co-authors measure pancreatic cancer risk in BRCA carriers in a 2025 study. People with harmful changes in BRCA1 or BRCA2 face higher risk of this cancer, but exact numbers help guide care. The team follows a large group of confirmed carriers in Norway who had no pancreatic cancer before gene testing.
Cases come from the national cancer registry. Carriers show about three times the expected cases overall. Risk looks highest in female BRCA2 carriers and male BRCA1 carriers. Even so, the total risk by age seventy stays below three percent in those groups, the authors report.
Catalog record
| CREATOR | Eli Marie Grindedal, Manuela Zucknick, Sigrid Tronsli Hovland, Tom K Grimsrud, Lovise Mæhle |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |