Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma
Zhou Lu, Huanchen Shi, Rongshan Gao, Chengjie zhong, Wei Zhang, Jian Zhu, Jianhang Huang, Ronghua Liu, Yun Xing, Yiwei Chu, Haixiang Sun, Guoming Shi, Aiwu Ke, Jian Zhou, Jiabin Cai, Jia Fan, Pingting Gao, Cheng Huang · 2025
Read Liver-specific paraoxonase-1 alleviates regulatory T cell-driven immunosuppression via metabolic reprogramming in hepatocellular carcinoma by Zhou Lu, Huanchen Shi, Rongshan Gao, Chengjie zhong, Wei Zhang, Jian Zhu, Jianhang Huang, Ronghua Liu, Yun Xing, Yiwei Chu, Haixiang Sun, Guoming Shi, Aiwu Ke, Jian Zhou, Jiabin Cai, Jia Fan, Pingting Gao, Cheng Huang (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12701056.txt.
Description
Zhou Lu and co-authors report cancer research from two thousand twenty-five on a liver protein that may slow liver cancer. The protein, called PON1, is made only in the liver. Suppressive immune cells often shield liver tumors from attack, and the team asked whether this protein affects that shield.
They found the protein acts as a metabolic regulator. It promotes the breakdown of a factor that builds up when oxygen is low, which cuts lactic acid output by tumors. Less lactic acid means fewer suppressive cells gather, so the tumor grows more slowly. Patients with more of the protein fared better. Giving the protein directly slowed tumors in models, and a plant compound that raises it improved response to immunotherapy in mice.
Catalog record
| CREATOR | Zhou Lu, Huanchen Shi, Rongshan Gao, Chengjie zhong, Wei Zhang, Jian Zhu, Jianhang Huang, Ronghua Liu, Yun Xing, Yiwei Chu, Haixiang Sun, Guoming Shi, Aiwu Ke, Jian Zhou, Jiabin Cai, Jia Fan, Pingting Gao, Cheng Huang |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |