Exploring the antidepressant-like effect of stigmasterol using network pharmacology with molecular docking and in vivo experimental validation
Robert Peter Biney, Isaac Blessed Mensah, Akua Afriyie Karikari, Aaron Opoku Antwi, Abigail Wortsi, Albert Dwamena Nkansah, Gyan Nana Kyere Barnieh, Isaac Tabiri Henneh · 2025
Read Exploring the antidepressant-like effect of stigmasterol using network pharmacology with molecular docking and in vivo experimental validation by Robert Peter Biney, Isaac Blessed Mensah, Akua Afriyie Karikari, Aaron Opoku Antwi, Abigail Wortsi, Albert Dwamena Nkansah, Gyan Nana Kyere Barnieh, Isaac Tabiri Henneh (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12700967.txt.
Description
Robert Biney and seven co-authors shared a study in twenty twenty-five. It is about stigmasterol, a plant sterol found in every vegetable oil. They test it as a candidate antidepressant. Computational network analysis first mapped forty genes. At those genes, the compound's predicted targets meet the genes of depression. A handful of hubs stood out. They include AKT1 and the monoamine enzymes.
Docking simulations checked the fit of the compound. Then came the animal work. Mice given stigmasterol struggled less in two tests. Those were the standard swim and suspension despair tests. When the team blocked monoamine production or storage, the effect went away. That confirmed the predicted mechanism in an experimental way. The pipeline is the template here. Computation proposes, and animals dispose. The authors present a dietary molecule with a traced, testable antidepressant pathway.
Catalog record
| CREATOR | Robert Peter Biney, Isaac Blessed Mensah, Akua Afriyie Karikari, Aaron Opoku Antwi, Abigail Wortsi, Albert Dwamena Nkansah, Gyan Nana Kyere Barnieh, Isaac Tabiri Henneh |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |