LBX2 promotes colorectal cancer progression via the glycosylation and lactylation positive feedback
Yiwen Jiang, Lude Wang, Lin Chen, Kai Shen, Jie Chang, Shicong Zheng, Zewei Chen, Chenyang Ge, Min Yu, Shian Yu, Haiping Lin · 2025
Read LBX2 promotes colorectal cancer progression via the glycosylation and lactylation positive feedback by Yiwen Jiang, Lude Wang, Lin Chen, Kai Shen, Jie Chang, Shicong Zheng, Zewei Chen, Chenyang Ge, Min Yu, Shian Yu, Haiping Lin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12700955.txt.
Description
Yiwen Jiang leads a team on a gene switch that drives bowel cancer. Their study from twenty twenty-five deals with LBX2, a growth control factor. Bowel cancer is a top cause of cancer death world wide.
Cutting LBX2 slowed cancer growth in lab and in mice. Gene tests found a direct target that lifts sugar use paths. That path boosts a growth hub and makes more lactate. Lactate then marks genes to raise LBX2 yet more. The loop feeds itself and speeds the cancer on. High LBX2 tumors may fall to a sugar block drug.
Catalog record
| CREATOR | Yiwen Jiang, Lude Wang, Lin Chen, Kai Shen, Jie Chang, Shicong Zheng, Zewei Chen, Chenyang Ge, Min Yu, Shian Yu, Haiping Lin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |