GSK3 phosphorylates and activates trehalose-6-phosphate synthase to improve trehalose production and thermotolerance in Ganoderma lucidum
Lingshuai Wang, Lingyan Shi, Hui Wang, Qiqi Han, Yuqing Hu, Qin Zheng, Zeyi Dong, Rui Liu, Mingwen Zhao, Huhui Chen · 2025
Read GSK3 phosphorylates and activates trehalose-6-phosphate synthase to improve trehalose production and thermotolerance in Ganoderma lucidum by Lingshuai Wang, Lingyan Shi, Hui Wang, Qiqi Han, Yuqing Hu, Qin Zheng, Zeyi Dong, Rui Liu, Mingwen Zhao, Huhui Chen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-12700916.txt.
Description
Lingshuai Wang and co-authors studied how a kinase boosts sugar production and heat tolerance in a medicinal fungus in two thousand twenty-five. The fungus, Ganoderma lucidum, makes trehalose, a sugar that protects cells under stress. The kinase GSK3 is known in many organisms, but its role in filamentous fungi was unclear.
Knocking down the kinase gene raised glycogen stores but cut energy output, growth, and heat tolerance. The kinase was shown to bind and phosphorylate the enzyme that starts trehalose making, at one specific site, which raised its activity. Strains with either gene knocked down made less trehalose and grew worse. Under heat, both proteins rose and trehalose built up, a protective response.
Catalog record
| CREATOR | Lingshuai Wang, Lingyan Shi, Hui Wang, Qiqi Han, Yuqing Hu, Qin Zheng, Zeyi Dong, Rui Liu, Mingwen Zhao, Huhui Chen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |