From synaptic guardian to neurodegenerative culprit: rewiring the amyloid-β feedback loop in Alzheimer’s disease
Joachim Herz · 2025
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Description
Joachim Herz, writing alone, rethinks the role of amyloid-beta in Alzheimer's disease, in a commentary dated twenty twenty-five. The short protein was long cast as mere waste that harms the brain. Herz weaves new findings into a fresh frame.
Free, loose copies of the protein help build and tune synapses, he argues. Clumped copies act as a brake on excited circuits, a guard that can turn harmful with age and swelling. The loop links brain activity, protein output, and synapse tuning. When it slips, protein control fails and lasting brain swelling follows.
Catalog record
| CREATOR | Joachim Herz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |